Product Number |
P100960_T100 |
Product Page |
www.avivasysbio.com/pc4-antibody-middle-region-p100960-t100.html |
Name |
PC4 Antibody - middle region (P100960_T100) |
Protein Size (# AA) |
127 amino acids |
Molecular Weight |
14kDa |
NCBI Gene Id |
10923 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
SUB1 homolog (S. cerevisiae) |
Description |
|
Alias Symbols |
P15, PC4, p14 |
Peptide Sequence |
Synthetic peptide located within the following region: NMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKGISLNPEQWS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Banerjee,S., et al., (2004) Cell.Biol.24(5),2052-2062 |
Description of Target |
PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity. |
Protein Interactions |
HUWE1; SUB1; UBC; rev; CLK4; CDK2; HNF4A; FN1; CSNK2A1; SMURF1; RPL18A; LAMP2; CDC5L; APP; YWHAZ; GTF3C1; ELAVL1; SUMO2; HDGF; Shoc2; Kif1c; POLR2B; POLR2A; CBX5; RCOR1; REST; BANF1; ADAP1; GTF2A1L; EP300; POU2AF1; CSTF2; TBP; TAF1; PCNA; HSF1; PSIP1; SP1 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SUB1 (P100960_T100) antibody |
Blocking Peptide |
For anti-SUB1 (P100960_T100) antibody is Catalog # AAP31317 (Previous Catalog # AAPP02067) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PC4 |
Uniprot ID |
P53999 |
Protein Name |
Activated RNA polymerase II transcriptional coactivator p15 |
Sample Type Confirmation |
There is BioGPS gene expression data showing that SUB1 is expressed in HepG2 |
Protein Accession # |
NP_006704 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_006713 |
Tested Species Reactivity |
Human |
Gene Symbol |
SUB1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Yeast, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 91%; Zebrafish: 100% |
Image 1 | Human Liver
| Human Liver |
|
Image 2 | Human HepG2
| WB Suggested Anti-PC4 Antibody Titration: 0.5-1.0ug/ml Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that SUB1 is expressed in HepG2 |
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