| Product Number |
P100947_T100 |
| Product Page |
www.avivasysbio.com/junb-antibody-c-terminal-region-p100947-t100.html |
| Name |
JUNB Antibody - C-terminal region (P100947_T100) |
| Protein Size (# AA) |
347 amino acids |
| Molecular Weight |
36kDa |
| NCBI Gene Id |
3726 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Jun B proto-oncogene |
| Description |
|
| Alias Symbols |
AP-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Troen,G., (2004) J Mol Diagn 6 (4), 297-307 |
| Description of Target |
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. |
| Protein Interactions |
BATF; FOS; RFWD2; C19orf68; USP24; TCERG1; ZNF595; PKIA; MAP2; APLP2; FOSL1; DDIT3; ATF3; BATF2; BATF3; TCL1A; FOSL2; NPM1; NEU1; SMAD4; HOXA7; BDNF; ATF4; MAPK6; UBC; TDG; SET; SAT1; MAPK9; BRCA1; SUMO2; Cebpb; EP300; SMURF1; YY1; CREBBP; SMARCA4; JDP2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-JUNB (P100947_T100) antibody |
| Blocking Peptide |
For anti-JUNB (P100947_T100) antibody is Catalog # AAP31302 (Previous Catalog # AAPP02051) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human JUNB |
| Uniprot ID |
P17275 |
| Protein Name |
Transcription factor jun-B |
| Protein Accession # |
NP_002220 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_002229 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
JUNB |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Sheep, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 85% |
| Image 1 | Human 293T
 | WB Suggested Anti-JUNB Antibody Titration: 2.5ug/ml
ELISA Titer: 1:62500
Positive Control: Transfected 293T |
|
