Product Number |
P100878_T100 |
Product Page |
www.avivasysbio.com/tfap2a-antibody-c-terminal-region-p100878-t100.html |
Name |
TFAP2A Antibody - C-terminal region (P100878_T100) |
Protein Size (# AA) |
437 amino acids |
Molecular Weight |
48kDa |
NCBI Gene Id |
7020 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Description |
|
Alias Symbols |
AP-2, BOFS, AP2TF, TFAP2, AP-2alpha |
Peptide Sequence |
Synthetic peptide located within the following region: NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Li,M., et al., (2006) Int. J. Cancer 118 (4), 802-811 |
Description of Target |
TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicleAP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM]. |
Protein Interactions |
MKRN3; GSTO2; KCTD15; SUMO1; HECW2; SP1; BAG3; RB1; UBC; DAB2; Fcho2; EPAS1; SRA1; EPS15; KCTD1; EPN1; SH3BP4; UBE2I; AURKA; BRCA1; DNMT3A; ELAVL1; SUMO4; SUMO2; NPM1; YY1; PPARG; EPN2; CITED4; LDLRAP1; CITED2; EP300; MAGI1; WWP2; WWP1; HIP1; CASP6; CASP3 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-TFAP2A (P100878_T100) antibody |
Blocking Peptide |
For anti-TFAP2A (P100878_T100) antibody is Catalog # AAP31161 (Previous Catalog # AAPP01904) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human TFAP2A |
Uniprot ID |
P05549 |
Protein Name |
Transcription factor AP-2-alpha |
Publications |
Anti-TFAP2A P100878_T100 has recently been referenced in the following publications: Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 20547158 |
Protein Accession # |
NP_003211 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_003220 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
TFAP2A |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Guinea Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 92%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92% |
Image 1 | Human HepG2
| WB Suggested Anti-TFAP2A Antibody Titration: 1.25ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate |
|
Image 2 | Mouse Heart
| Host: Mouse Target Name: TFAP2A Sample Tissue: Mouse Heart Antibody Dilution: 1ug/ml |
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