| Product Number |
P100877_P050 |
| Product Page |
www.avivasysbio.com/runx1-antibody-middle-region-p100877-p050.html |
| Name |
RUNX1 Antibody - middle region (P100877_P050) |
| Protein Size (# AA) |
480 amino acids |
| Molecular Weight |
52kDa |
| NCBI Gene Id |
861 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Runt-related transcription factor 1 |
| Description |
|
| Alias Symbols |
AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, CBF2alpha, AML1-EVI-1, PEBP2alpha |
| Peptide Sequence |
Synthetic peptide located within the following region: CTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Takeshita,M., (2008) Leukemia 22 (6), 1241-1249 |
| Description of Target |
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with severaltypes of leukemia. Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. |
| Protein Interactions |
YAP1; UBC; HDAC11; SOX2; SMAD3; CTBP1; RUNX1; FOXP3; NCOR2; MYC; NOTCH1; UXT; CTBP2; KAT6A; PML; CREBBP; CBFB; PRMT1; HLA-DMA; HDAC2; HDAC1; CBFA2T3; RUNX1T1; CBFA2T2; ELAVL1; DNMT1; SPEN; RBM14; KMT2A; COPRS; HDAC3; TAL1; CDK1; SMARCC1; SMARCB1; SMARCA4; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RUNX1 (P100877_P050) antibody |
| Blocking Peptide |
For anti-RUNX1 (P100877_P050) antibody is Catalog # AAP31159 (Previous Catalog # AAPP01902) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RUNX1 |
| Uniprot ID |
B2RMS4 |
| Protein Name |
Runt-related transcription factor 1 |
| Sample Type Confirmation |
RUNX1 is strongly supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_001745 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001754 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RUNX1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 92%; Zebrafish: 85% |
| Image 1 | Human 721_B
 | WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysateRUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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