| Product Number |
P100874_P050 |
| Product Page |
www.avivasysbio.com/nfkbil2-antibody-middle-region-p100874-p050.html |
| Name |
NFKBIL2 Antibody - middle region (P100874_P050) |
| Protein Size (# AA) |
1219 amino acids |
| Molecular Weight |
133kDa |
| NCBI Gene Id |
4796 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Tonsoku-like, DNA repair protein |
| Description |
|
| Alias Symbols |
IKBR, SEMDSP, NFKBIL2 |
| Peptide Sequence |
Synthetic peptide located within the following region: RAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007) |
| Description of Target |
NFKBIL2 is thought to be a negative regulator of NF-kappa-B mediated transcription. It may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. |
| Protein Interactions |
HIST3H3; MCM6; MCM2; MMS22L; ASF1B; ASF1A; UBC; MYC; MAU2; SLC25A5; SUPT16H; SUGT1; AIFM1; HIST1H2BL; XRCC5; SSRP1; SLC25A3; TONSL; MCM4; HIST1H2AE; HIST1H1B; HIST1H1C; XRCC6; GSK3B; MCM7; MCM5; MCM3; EWSR1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-TONSL (P100874_P050) antibody |
| Blocking Peptide |
For anti-TONSL (P100874_P050) antibody is Catalog # AAP31101 (Previous Catalog # AAPP01840) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NFKBIL2 |
| Uniprot ID |
Q96HA7 |
| Protein Name |
Tonsoku-like protein |
| Protein Accession # |
NP_038460 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_013432 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
TONSL |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 84%; Human: 100%; Mouse: 83%; Rat: 83% |
| Image 1 | Human 293T
 | WB Suggested Anti-NFKBIL2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 293T cell lysate |
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