Product Number |
P100841_P050 |
Product Page |
www.avivasysbio.com/irf8-antibody-n-terminal-region-p100841-p050.html |
Name |
IRF8 Antibody - N-terminal region (P100841_P050) |
Protein Size (# AA) |
426 amino acids |
Molecular Weight |
48kDa |
NCBI Gene Id |
3394 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Interferon regulatory factor 8 |
Description |
|
Alias Symbols |
ICSBP, IRF-8, ICSBP1, IMD32A, IMD32B, H-ICSBP |
Peptide Sequence |
Synthetic peptide located within the following region: MFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRC |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Weisz,A., et al., (1992) J. Biol. Chem. 267 (35), 25589-25596 |
Description of Target |
Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection. |
Protein Interactions |
SPI1; IRF1; TOP1; ZBTB17; PDGFRB; CBL; UBC; COPS4; COPS5; COPS6; COPS2; MID1; IRF6; GPS1; CDK4; SQSTM1; TRAF6; SMURF2; IRF2; TRIM21; IRF8; ETV6; RELA; NFKB1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
|
Datasheets/Manuals |
Printable datasheet for anti-IRF8 (P100841_P050) antibody |
Blocking Peptide |
For anti-IRF8 (P100841_P050) antibody is Catalog # AAP31198 (Previous Catalog # AAPP01941) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human IRF8 |
Uniprot ID |
Q02556 |
Protein Name |
Interferon regulatory factor 8 |
Protein Accession # |
NP_002154 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_002163 |
Tested Species Reactivity |
Human |
Gene Symbol |
IRF8 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | Human DLD1 Whole Cell
| Host: Rabbit Target Name: IRF8 Sample Tissue: Human DLD1 Whole Cell Antibody Dilution: 1ug/ml |
|
Image 2 | Human Intestine
| Immunohistochemistry with Human Intestine tissue |
|
Image 3 | Human Liver
| Immunohistochemistry with Human Liver cell lysate tissue |
|
Image 4 | Human Jurkat Whole Cell
| Host: Rabbit Target Name: IRF8 Sample Tissue: Human Jurkat Whole Cell Antibody Dilution: 3ug/ml |
|