IRF8 Antibody - N-terminal region (P100841_P050)

Data Sheet
 
Product Number P100841_P050
Product Page www.avivasysbio.com/irf8-antibody-n-terminal-region-p100841-p050.html
Name IRF8 Antibody - N-terminal region (P100841_P050)
Protein Size (# AA) 426 amino acids
Molecular Weight 48kDa
NCBI Gene Id 3394
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Interferon regulatory factor 8
Description
Alias Symbols ICSBP, IRF-8, ICSBP1, IMD32A, IMD32B, H-ICSBP
Peptide Sequence Synthetic peptide located within the following region: MFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRC
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Weisz,A., et al., (1992) J. Biol. Chem. 267 (35), 25589-25596
Description of Target Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection.
Protein Interactions SPI1; IRF1; TOP1; ZBTB17; PDGFRB; CBL; UBC; COPS4; COPS5; COPS6; COPS2; MID1; IRF6; GPS1; CDK4; SQSTM1; TRAF6; SMURF2; IRF2; TRIM21; IRF8; ETV6; RELA; NFKB1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
WBY
SPR
YCHAROS
Datasheets/Manuals Printable datasheet for anti-IRF8 (P100841_P050) antibody
Blocking Peptide For anti-IRF8 (P100841_P050) antibody is Catalog # AAP31198 (Previous Catalog # AAPP01941)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human IRF8
Uniprot ID Q02556
Protein Name Interferon regulatory factor 8
Protein Accession # NP_002154
Purification Affinity Purified
Nucleotide Accession # NM_002163
Tested Species Reactivity Human
Gene Symbol IRF8
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Image 1
Human DLD1 Whole Cell
Host: Rabbit
Target Name: IRF8
Sample Tissue: Human DLD1 Whole Cell
Antibody Dilution: 1ug/ml
Image 2
Human Intestine
Immunohistochemistry with Human Intestine tissue
Image 3
Human Liver
Immunohistochemistry with Human Liver cell lysate tissue
Image 4
Human Jurkat Whole Cell
Host: Rabbit
Target Name: IRF8
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 3ug/ml
 

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