NR2C1 Antibody - middle region (P100813_P050)

Data Sheet
 
Product Number P100813_P050
Product Page www.avivasysbio.com/nr2c1-antibody-middle-region-p100813-p050.html
Name NR2C1 Antibody - middle region (P100813_P050)
Protein Size (# AA) 603 amino acids
Molecular Weight 67kDa
NCBI Gene Id 7181
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Nuclear receptor subfamily 2, group C, member 1
Description
Alias Symbols TR2
Peptide Sequence Synthetic peptide located within the following region: ELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Lin,Y.L., (2006) Biochem. Biophys. Res. Commun. 350 (2), 430-436
Description of Target The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Protein Interactions PSPC1; MBD3; SIN3A; RCOR1; KDM1A; POLD3; TRIM28; RBM39; MTA2; MTA1; HDAC3; NR2C2; SMARCA4; SFPQ; RBBP7; RBBP4; NONO; HDAC2; HDAC1; HCFC1; DNMT1; CHD4; NUDT3; UBC; PML; HDAC4; NRIP1; AR; ESR1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-NR2C1 (P100813_P050) antibody
Blocking Peptide For anti-NR2C1 (P100813_P050) antibody is Catalog # AAP31157 (Previous Catalog # AAPP01896)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human NR2C1
Uniprot ID Q15625
Protein Name Nuclear receptor subfamily 2 group C member 1
Sample Type Confirmation

NR2C1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_003288
Purification Affinity Purified
Nucleotide Accession # NM_003297
Tested Species Reactivity Human
Gene Symbol NR2C1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 80%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 100%; Rat: 93%
Image 1
Human Jurkat
WB Suggested Anti-NR2C1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysateNR2C1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
 

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