| Product Number |
P100806_P050 |
| Product Page |
www.avivasysbio.com/etv6-antibody-n-terminal-region-p100806-p050.html |
| Name |
ETV6 Antibody - N-terminal region (P100806_P050) |
| Protein Size (# AA) |
452 amino acids |
| Molecular Weight |
53kDa |
| NCBI Gene Id |
2120 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ets variant 6 |
| Description |
|
| Alias Symbols |
TEL, THC5, TEL/ABL |
| Peptide Sequence |
Synthetic peptide located within the following region: WAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHIL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Rubnitz,J.E., (2008) J. Clin. Oncol. 26 (13), 2186-2191 |
| Description of Target |
ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. it contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
AP1M1; WDYHV1; UBC; SUMO1; NEDD8; ETV6; SUMO2; PIN1; HDAC6; SOX2; TRAF3; SOCS3; SOCS1; PDGFRB; ELAVL1; UBE2I; NCOR1; SIN3A; HDAC3; L3MBTL1; SMURF1; HDAC9; KAT5; FLI1; IRF8; SKP1; FBXL6; GAB2; GRB2; CRKL; ACTA1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ETV6 (P100806_P050) antibody |
| Blocking Peptide |
For anti-ETV6 (P100806_P050) antibody is Catalog # AAP31148 (Previous Catalog # AAPP01887) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ETV6 |
| Uniprot ID |
P41212 |
| Protein Name |
Transcription factor ETV6 |
| Sample Type Confirmation |
ETV6 is supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_001978 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001987 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ETV6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human 721_B
 | WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 721_B cell lysateETV6 is supported by BioGPS gene expression data to be expressed in 721_B |
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