| Product Number |
P100799_P050 |
| Product Page |
www.avivasysbio.com/ssrp1-antibody-middle-region-p100799-p050.html |
| Name |
SSRP1 Antibody - middle region (P100799_P050) |
| Protein Size (# AA) |
709 amino acids |
| Molecular Weight |
81kDa |
| Subunit |
SSRP1 |
| NCBI Gene Id |
6749 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Structure specific recognition protein 1 |
| Description |
|
| Alias Symbols |
FACT, T160, FACT80 |
| Peptide Sequence |
Synthetic peptide located within the following region: MKEYEGGRGESSKRDKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESF |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,Y., (2007) J. Biol. Chem. 282 (10), 6936-6945 |
| Description of Target |
SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
SUMO2; SUMO3; ATRX; UBC; EED; RNF2; SEC24C; CUL1; CSDE1; ATP6V1B2; DIABLO; SBNO1; PBDC1; EXOSC10; CSNK2A1; PNKP; VCAM1; SRPK1; ITGA4; FMNL1; SUPT16H; CENPA; LEO1; PAF1; PHGDH; SF3B1; NCSTN; RTF1; RBM14; SAP18; CTR9; S100A9; NOP2; HMGB1; HIST1H2BB; DHX9; C |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SSRP1 (P100799_P050) antibody |
| Blocking Peptide |
For anti-SSRP1 (P100799_P050) antibody is Catalog # AAP31140 (Previous Catalog # AAPP01879) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human SSRP1 |
| Uniprot ID |
Q08945 |
| Protein Name |
FACT complex subunit SSRP1 |
| Protein Accession # |
NP_003137 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003146 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SSRP1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Human: 100%; Mouse: 100%; Rat: 100% |
| Image 1 | Human Spleen
 | WB Suggested Anti-SSRP1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Spleen |
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