| Product Number |
P100601_P050-FITC |
| Product Page |
www.avivasysbio.com/ctnnb1-antibody-c-terminal-region-fitc-p100601-p050-fitc.html |
| Name |
CTNNB1 Antibody - C-terminal region : FITC (P100601_P050-FITC) |
| Protein Size (# AA) |
781 amino acids |
| Molecular Weight |
85kDa |
| Conjugation |
FITC: Fluorescein Isothiocyanate |
| NCBI Gene Id |
1499 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Catenin (cadherin-associated protein), beta 1, 88kDa |
| Alias Symbols |
EVR7, CTNNB, MRD19, NEDSDV, armadillo |
| Peptide Sequence |
Synthetic peptide located within the following region: RTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
| Reference |
Jiang,X., (2008) Cancer Cell 13 (6), 529-541 |
| Description of Target |
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 DA216720.1 1-54 55-2626 X87838.1 1-2572 2627-3720 AC104307.2 83770-84863 |
| Protein Interactions |
PPARD; PLA2G4A; FBXO45; BTRC; SUMO1; UBC; HUWE1; CDH5; CDH2; TCF4; TBL1X; SOX1; SKP1; RNF220; CACYBP; FBXW11; SUMO2; SIAH1; Apc2; COPS5; RNF14; CDH1; SP1; KCTD1; MDM2; UBE2B; GSK3B; NEK2; RBX1; PTGS2; STRN3; LATS2; APC; ELAVL1; AMOT; ABL1; AXIN1; CBL; LEF |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-CTNNB1 (P100601_P050-FITC) antibody |
| Blocking Peptide |
For anti-CTNNB1 (P100601_P050-FITC) antibody is Catalog # AAP30904 (Previous Catalog # AAPP01628) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C-terminal region of human CTNNB1 |
| Uniprot ID |
P35222 |
| Protein Name |
Catenin beta-1 |
| Sample Type Confirmation |
CTNNB1 is supported by BioGPS gene expression data to be expressed in HCT116 |
| Protein Accession # |
NP_001895 |
| Nucleotide Accession # |
NM_001904 |
| Gene Symbol |
CTNNB1 |
| Predicted Species Reactivity |
Human, Mouse, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
CHIP, WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Zebrafish: 100% |
| Image 1 | |
