Product Number |
P100596_P050 |
Product Page |
www.avivasysbio.com/prdm1-antibody-middle-region-p100596-p050.html |
Name |
PRDM1 Antibody - middle region (P100596_P050) |
Protein Size (# AA) |
825 amino acids |
Molecular Weight |
92 kDa |
NCBI Gene Id |
639 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
PR domain containing 1, with ZNF domain |
Description |
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Alias Symbols |
BLIMP1, PRDI-BF1 |
Peptide Sequence |
Synthetic peptide located within the following region: VEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNMGNGLLSSGCSLYES |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Diehl,S.A., (2008) J. Immunol. 180 (7), 4805-4815 |
Description of Target |
PRDM1 is a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. |
Protein Interactions |
PRMT5; SENP1; EHMT2; PIAS1; SUMO1; IRF2; IRF1; HDAC2; HDAC1; HIST1H1A; MS4A1; HSP90AA1; ATXN1; ELAVL1; KDM1A; IRF4; TLE2; TLE1; AES; PRMT7; HIST2H3A; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PRDM1 (P100596_P050) antibody |
Additional Information |
IHC Information: Pancreas IHC Information: Spleen |
Blocking Peptide |
For anti-PRDM1 (P100596_P050) antibody is Catalog # AAP30899 (Previous Catalog # AAPP01623) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PRDM1 |
Uniprot ID |
Q86WM7 |
Protein Name |
PR domain zinc finger protein 1 |
Publications |
VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. Cancer Cell. 28, 210-24 (2015). 26212250 |
Protein Accession # |
NP_878911 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_182907 |
Tested Species Reactivity |
Human |
Gene Symbol |
PRDM1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 84%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 92%; Rat: 92% |
Image 1 | Human Spleen
| Immunohistochemistry with Spleen cell lysate tissue at an antibody concentration of 5.0ug/ml using anti-PRDM1 antibody (P100596_P050) |
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Image 2 | Human Pancreas
| Anti-BLIMP-1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. |
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Image 3 |
| 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The peptide sequence is present in a 77 kDa isoform. The protein may be modified by glycosylation.
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