| Product Number |
OPSN00008 |
| Product Page |
www.avivasysbio.com/human-ace2-recombinant-protein-opsn00008.html |
| Name |
Human ACE2 Recombinant Protein (OPSN00008) |
| Protein Size (# AA) |
AA 19-615 amino acids |
| Molecular Weight |
75kDa |
| Tag |
None |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
59272 |
| Host |
Sf9 Baculovirus |
| Purity |
90% |
| Concentration |
0.37 mg/mL |
| Gene Full Name |
angiotensin converting enzyme 2 |
| Description |
The Human ACE2 (Angiotensin-converting Enzyme 2) Recombinant Protein (OPSN00008) (amino acids 19-615) is expressed in Sf9 Baculovirus cells and purified using an Fc tag with Protein A/G chromatography followed by cleavage of the Fc tag. Useful for antibody or Coronavirus Spike interaction assays in a variety of formats. |
| Alias Symbols |
ACEH |
| Product Format |
Liquid. 50 mM Tris-HCL, 1M NaCl, pH 7.5 |
| Description of Target |
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. |
| Reconstitution and Storage |
Store at -20C |
| Datasheets/Manuals |
Printable datasheet for OPSN00008 |
| Formulation |
50 mM Tris-HCL, 1M NaCl, pH 7.5 |
| Uniprot ID |
Q9BYF1 |
| Protein Name |
angiotensin-converting enzyme 2 |
| Purification |
Protein G followed by cleavage of Fc |
| Gene Symbol |
ACE2 |
| Predicted Species Reactivity |
Human |
| Application |
ELISA, IA, AA, FN |
| Image 1 | ACE2 SDS-PAGE
 | Purified protein (1 ug) was loaded onto a 4-12% Bis-tris SDS-PAGE gel, electrophoresed and coomassie stained to demonstrate recombinant protein integrity and purity. Gels were imaged with a white background post destain. |
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