| Product Number |
OPPA01890 |
| Product Page |
www.avivasysbio.com/4-1bbl-protein-oppa01890.html |
| Name |
4 1BBL Protein (OPPA01890) |
| Protein Size (# AA) |
Recombinant amino acids |
| NCBI Gene Id |
8744 |
| Host |
E. Coli |
| Purity |
Greater than 95.0% as determined by SDS-PAGE |
| Alias Symbols |
CD137L, TNLG5A, 4-1BB-L |
| Peptide Sequence |
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTGGLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE. |
| Product Format |
Recombinant 4-1BBL contains 20mM Tris buffer pH-8, 100mM NaCl and 20% glycerol. Physical appearance: Sterile Filtered colorless solution. |
| Description of Target |
Recombinant Human 4-1BB Ligand |
| Reconstitution and Storage |
4-1BBL although stable at 10C for 3 weeks, should be stored desiccated below -18C. Please prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OPPA01890 |
| Additional Information |
Product Introduction: 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin
Product Description: TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (71-254 a.a.) and having a molecular mass of 23.8 kDa. The TNFSF9 His tag fusion protein is purified by proprietary chromatographic techniques. |
| Uniprot ID |
P41273 |
| Protein Name |
Tumor necrosis factor ligand superfamily member 9 |
| Protein Accession # |
NP_003802.1 |
| Gene Symbol |
4 1BBL |
| Predicted Species Reactivity |
Human |
| Image 1 | |
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