| Product Number |
OPPA01766 |
| Product Page |
www.avivasysbio.com/srage-protein-oppa01766.html |
| Name |
sRAGE Protein (OPPA01766) |
| Protein Size (# AA) |
Recombinant amino acids |
| Molecular Weight |
36.5 kDa |
| Tag |
N-terminal His-tag |
| NCBI Gene Id |
177 |
| Host |
E. Coli |
| Purity |
Greater than 95% as determined by SDS-PAGE. |
| Concentration |
0.5 mg/ml (prior to lyophilization) |
| Alias Symbols |
RAGE, sRAGE, SCARJ1 |
| Product Format |
Lyophilized 30mM acetate buffer (pH 4) |
| Description of Target |
sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide. sRAGE Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids. |
| Reconstitution and Storage |
Store lyophilized protein at -20°C. Add 0.1M Acetate buffer (pH 4) to a working concentration of 0.5 mg/ml and let the lyophilized pellet dissolve completely. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Protein Sequence |
MRGSHHHHHH GMASAQNITA RIGEPLVLKC KGAPKKPPQR LEWKLNTGRT EAWKVLSPQG GGPWDSVARV LPNGSLFLPAV GIQDEGIFRCQ AMNRNGKETKS NYRVRVYQIP GKPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGKPL VPNEKGVSVK EQTRRHPETG LFTLQSELMV TPARGGDPRP TFSCSFSPGL PRHRALRTAP IQPRVWEPVPL EEVQLVVEPE GGAVAPGGTV TLTCEVPAQP SPQIHWMKDGVP LPLPPSPVLI LPEIGPQDQG TYSCVATHSS HGPQESRAVS ISIIEPGEEG PTAGEGFDKV REAEDSPQHM |
| Datasheets/Manuals |
Printable datasheet for OPPA01766 |
| Uniprot ID |
Q15109 |
| Protein Name |
Advanced glycosylation end product-specific receptor |
| Protein Accession # |
NP_001127.1 |
| Purification |
Proprietary chromatographic techniques. |
| Gene Symbol |
sRAGE |
| Predicted Species Reactivity |
Human |
| Image 1 | sRAGE Protein (OPPA01766)
 | |
|
|
