| Product Number |
OPCD06698 |
| Product Page |
www.avivasysbio.com/ripk3-recombinant-protein-opcd06698.html |
| Name |
RIPK3 Recombinant Protein (OPCD06698) |
| Protein Size (# AA) |
Leu16~Cys239 amino acids |
| Molecular Weight |
28kDa |
| Tag |
N-terminal His Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
56532 |
| Host |
E.coli |
| Purity |
> 95% |
| Concentration |
200 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
receptor-interacting serine-threonine kinase 3 |
| Alias Symbols |
2610528K09Rik;AW107945;mRIP3;R;receptor interacting protein 3;Receptor-interacting protein 3;receptor-interacting serine/threonine-protein kinase 3;Rip3;RIP-3;RIP-like protein kinase 3. |
| Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Description of Target |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| Reconstitution and Storage |
2°C to 8°C|-80°C |
| Datasheets/Manuals |
Printable datasheet for RIPK3 Recombinant Protein (OPCD06698) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| Additional Information |
Residues: Leu16-Cys239 |
| Additional Information |
Subcellular Location: Cytoplasm. Cell membrane. Mitochondrion. |
| Uniprot ID |
Q9QZL0 |
| Protein Name |
Receptor-interacting serine/threonine-protein kinase 3 |
| Protein Accession # |
NP_064339.2 |
| Nucleotide Accession # |
NM_019955.2 |
| Gene Symbol |
Ripk3 |
| Predicted Species Reactivity |
Mouse|Mus musculus |
| Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
| Image 1 | SDS-PAGE
 | RIPK3 Recombinant Protein (OPCD06698) using SDS-PAGE |
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