| Product Number |
OPCD02687 |
| Product Page |
www.avivasysbio.com/ddit3-recombinant-protein-opcd02687.html |
| Name |
DDIT3 Recombinant Protein (OPCD02687) |
| Protein Size (# AA) |
Met1~Ala168 amino acids |
| Molecular Weight |
55kDa |
| Tag |
N-terminal His and GST Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
13198 |
| Host |
E.coli |
| Purity |
>90% |
| Concentration |
200 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
DNA-damage inducible transcript 3 |
| Alias Symbols |
AltDDIT3;alternative DDIT3 proteins;C/EBP homoologous protein 10;C/EBP zeta;C/EBP-homologous protein;c/EBP-homologous protein 10;CCAAT/enhancer-binding protein homologous protein;ch;chop;CHOP-;CHOP10;CHOP-10;DDIT-3;DNA damage-inducible transcript 3 protein;gadd15;gadd153;growth arrest and DNA-damage-inducible protein GADD153. |
| Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Description of Target |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling. |
| Reconstitution and Storage |
2°C to 8°C|-80°C |
| Datasheets/Manuals |
Printable datasheet for DDIT3 Recombinant Protein (OPCD02687) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| Additional Information |
Residues: Met1-Ala168 |
| Uniprot ID |
P35639 |
| Protein Name |
DNA damage-inducible transcript 3 protein |
| Protein Accession # |
NP_001277112.1 |
| Nucleotide Accession # |
NM_001290183.1 |
| Gene Symbol |
Ddit3 |
| Predicted Species Reactivity |
Mouse|Mus musculus |
| Application |
Ctrl (+), SDS-PAGE, WB |
| Image 1 | SDS-PAGE
 | DDIT3 Recombinant Protein (OPCD02687) using SDS-PAGE |
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