Product Number |
OPCD02224 |
Product Page |
www.avivasysbio.com/cilp-recombinant-protein-opcd02224.html |
Name |
CILP Recombinant Protein (OPCD02224) |
Protein Size (# AA) |
Pro604~His864 amino acids |
Molecular Weight |
60kDa |
Tag |
N-terminal His and GST Tag |
Conjugation |
Unconjugated |
NCBI Gene Id |
214425 |
Host |
E.coli |
Purity |
> 95% |
Concentration |
200 ug/mL (prior to lyoph) |
Source |
E.coli |
Gene Full Name |
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
Alias Symbols |
9830114D16;C130036G17Rik;cartilage intermediate layer protein 1;CILP-1. |
Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Description of Target |
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). |
Reconstitution and Storage |
2°C to 8°C|-80°C |
Datasheets/Manuals |
Printable datasheet for CILP Recombinant Protein (OPCD02224) |
Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
Additional Information |
Residues: Pro604-His864 |
Additional Information |
Subcellular Location: Secreted, extracellular space, extracellular matrix |
Uniprot ID |
Q66K08 |
Protein Name |
Cartilage intermediate layer protein 1 |
Protein Accession # |
NP_775561.1 |
Nucleotide Accession # |
NM_173385.2 |
Gene Symbol |
Cilp |
Predicted Species Reactivity |
Mouse|Mus musculus |
Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Image 1 | SDS-PAGE
| CILP Recombinant Protein (OPCD02224) using SDS-PAGE |
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