| Product Number |
OPCD01924 |
| Product Page |
www.avivasysbio.com/cav1-recombinant-protein-opcd01924.html |
| Name |
CAV1 Recombinant Protein (OPCD01924) |
| Protein Size (# AA) |
Ser2~Ser104 amino acids |
| Molecular Weight |
13 kDa |
| Tag |
N-terminal His Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
857 |
| Host |
E.coli |
| Purity |
> 97% |
| Concentration |
500 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
caveolin 1 |
| Alias Symbols |
BSCL3;caveolin 1, caveolae protein, 22kDa;caveolin-1;cell growth-inhibiting protein 32;CGL3;LCCNS;MSTP085;PPH3;VIP21. |
| Product Format |
Lyophilized 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300 |
| Description of Target |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). |
| Reconstitution and Storage |
Reconstitute in 20mM Tris, 150mM NaCl (pH 8.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Avoid repeated freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for CAV1 Recombinant Protein (OPCD01924) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Ser2-Ser104
Subcellular Location: Membrane
Isoelectric Point: 5.7 |
| Uniprot ID |
Q03135 |
| Protein Name |
Caveolin-1 |
| Protein Accession # |
NP_001744.2 |
| Nucleotide Accession # |
NM_001753.4 |
| Gene Symbol |
CAV1 |
| Predicted Species Reactivity |
Homo sapiens|Human |
| Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
| Image 1 | SDS-PAGE
 | CAV1 Recombinant Protein (OPCD01924) using SDS-PAGE |
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