| Product Number |
OPCD00998 |
| Product Page |
www.avivasysbio.com/aatf-recombinant-protein-opcd00998.html |
| Name |
AATF Recombinant Protein (OPCD00998) |
| Protein Size (# AA) |
Ser273~Ser477 amino acids |
| Molecular Weight |
54kDa |
| Tag |
N-terminal His and GST Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
26574 |
| Host |
E.coli |
| Purity |
> 95% |
| Concentration |
200 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
apoptosis antagonizing transcription factor |
| Alias Symbols |
Apoptosis-antagonizing transcription factor;BFR2;CHE1;CHE-1;DED;protein AATF;rb-binding protein Che-1. |
| Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Description of Target |
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Reconstitution and Storage |
2°C to 8°C|-80°C |
| Datasheets/Manuals |
Printable datasheet for AATF Recombinant Protein (OPCD00998) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| Additional Information |
Residues: Ser273-Ser477 |
| Additional Information |
Subcellular Location: Nucleus, nucleolus |
| Uniprot ID |
Q9NY61 |
| Protein Name |
Protein AATF |
| Protein Accession # |
NP_036270.1 |
| Nucleotide Accession # |
NM_012138.3 |
| Gene Symbol |
AATF |
| Predicted Species Reactivity |
Homo sapiens|Human |
| Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
| Image 1 | SDS-PAGE
 | AATF Recombinant Protein (OPCD00998) using SDS-PAGE |
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