| Product Number |
OPCD00980 |
| Product Page |
www.avivasysbio.com/a2m-recombinant-protein-opcd00980.html |
| Name |
A2M Recombinant Protein (OPCD00980) |
| Protein Size (# AA) |
Ser616~Val856 amino acids |
| Molecular Weight |
28kDa |
| Tag |
N-terminal His Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
2 |
| Host |
E.coli |
| Purity |
> 95% |
| Concentration |
200 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
alpha-2-macroglobulin |
| Alias Symbols |
A2MD;alpha-2-M;alpha-2-macroglobulin;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;CPAMD5;FWP007;S863-7. |
| Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Description of Target |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Reconstitution and Storage |
2°C to 8°C|-80°C |
| Datasheets/Manuals |
Printable datasheet for A2M Recombinant Protein (OPCD00980) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| Additional Information |
Residues: Ser616-Val856 |
| Uniprot ID |
P01023 |
| Protein Name |
Alpha-2-macroglobulin |
| Protein Accession # |
NP_000005.2 |
| Nucleotide Accession # |
NM_000014.4 |
| Gene Symbol |
A2M |
| Predicted Species Reactivity |
Homo sapiens|Human |
| Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
| Image 1 | SDS-PAGE
 | A2M Recombinant Protein (OPCD00980) using SDS-PAGE |
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