Product Number |
OPCD00606 |
Product Page |
www.avivasysbio.com/dmpk-recombinant-protein-opcd00606.html |
Name |
DMPK Recombinant Protein (OPCD00606) |
Protein Size (# AA) |
Met1~Ile201 amino acids |
Molecular Weight |
27kDa |
Tag |
N-terminal His Tag |
Conjugation |
Unconjugated |
NCBI Gene Id |
1760 |
Host |
E.coli |
Purity |
> 95% |
Concentration |
200 ug/mL (prior to lyoph) |
Source |
E.coli |
Gene Full Name |
DM1 protein kinase |
Alias Symbols |
DM;DM protein kinase;DM1;DM1 protein kinase;DM1PK;DMK;DM-kinase;DMPK;dystrophia myotonica protein kinase;MDPK;MT-PK;myotonic dystrophy associated protein kinase;Myotonic dystrophy protein kinase;myotonin protein kinase A;myotonin-protein kinase;thymopoietin homolog. |
Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Description of Target |
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
Reconstitution and Storage |
2°C to 8°C|-80°C |
Datasheets/Manuals |
Printable datasheet for DMPK Recombinant Protein (OPCD00606) |
Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
Additional Information |
Residues: Met1-Ile201 |
Uniprot ID |
Q09013 |
Protein Name |
Myotonin-protein kinase |
Protein Accession # |
NP_001075029.1 |
Nucleotide Accession # |
NM_001081560.2 |
Gene Symbol |
DMPK |
Predicted Species Reactivity |
Homo sapiens|Human |
Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Image 1 | SDS-PAGE
| DMPK Recombinant Protein (OPCD00606) using SDS-PAGE |
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