DMPK Recombinant Protein (OPCD00606)

Data Sheet
 
Product Number OPCD00606
Product Page www.avivasysbio.com/dmpk-recombinant-protein-opcd00606.html
Name DMPK Recombinant Protein (OPCD00606)
Protein Size (# AA) Met1~Ile201 amino acids
Molecular Weight 27kDa
Tag N-terminal His Tag
Conjugation Unconjugated
NCBI Gene Id 1760
Host E.coli
Purity > 95%
Concentration 200 ug/mL (prior to lyoph)
Source E.coli
Gene Full Name DM1 protein kinase
Alias Symbols DM;DM protein kinase;DM1;DM1 protein kinase;DM1PK;DMK;DM-kinase;DMPK;dystrophia myotonica protein kinase;MDPK;MT-PK;myotonic dystrophy associated protein kinase;Myotonic dystrophy protein kinase;myotonin protein kinase A;myotonin-protein kinase;thymopoietin homolog.
Product Format Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Description of Target Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Reconstitution and Storage 2°C to 8°C|-80°C
Datasheets/Manuals Printable datasheet for DMPK Recombinant Protein (OPCD00606)
Additional Information Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Additional Information Residues: Met1-Ile201
Uniprot ID Q09013
Protein Name Myotonin-protein kinase
Protein Accession # NP_001075029.1
Nucleotide Accession # NM_001081560.2
Gene Symbol DMPK
Predicted Species Reactivity Homo sapiens|Human
Application Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Image 1
SDS-PAGE
DMPK Recombinant Protein (OPCD00606) using SDS-PAGE
 

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