| Product Number |
OPCD00124 |
| Product Page |
www.avivasysbio.com/dtnbp1-recombinant-protein-opcd00124.html |
| Name |
DTNBP1 Recombinant Protein (OPCD00124) |
| Protein Size (# AA) |
Asp110~Leu305 amino acids |
| Molecular Weight |
28kDa |
| Tag |
N-terminal His Tag |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
641528 |
| Host |
E.coli |
| Purity |
> 95% |
| Concentration |
200 ug/mL (prior to lyoph) |
| Source |
E.coli |
| Gene Full Name |
dystrobrevin binding protein 1 |
| Alias Symbols |
biogenesis of lysosome-related organelles complex 1 subunit 8;BLOC-1 subunit 8;distrobrevin binding protein 1;dysbindin;dysbindin-1;Dystrobrevin-binding protein 1. |
| Product Format |
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Description of Target |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. |
| Reconstitution and Storage |
2°C to 8°C|-80°C |
| Datasheets/Manuals |
Printable datasheet for DTNBP1 Recombinant Protein (OPCD00124) |
| Additional Information |
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| Additional Information |
Residues: Asp110-Leu305 |
| Uniprot ID |
Q5M834 |
| Protein Name |
Dysbindin |
| Protein Accession # |
NP_001032753.1 |
| Nucleotide Accession # |
NM_001037664.1 |
| Gene Symbol |
Dtnbp1 |
| Predicted Species Reactivity |
Rat|Rattus norvegicus |
| Application |
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
| Image 1 | SDS-PAGE
 | DTNBP1 Recombinant Protein (OPCD00124) using SDS-PAGE |
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