E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947)

Data Sheet
 
Product Number OPCA02947
Product Page www.avivasysbio.com/e7-recombinant-protein-human-papillomavirus-type-18-opca02947.html
Name E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947)
Protein Size (# AA) Recombinant amino acids
Molecular Weight 14 kDa
Tag N-terminal 6xHis-tagged
Host Human
Purity Greater than 90% as determined by SDS-PAGE.
Concentration Varies by lot. See vial for exact concentration.
Source Yeast
Protein Range 1-105 aa
Alias Symbols E7Protein E7
Peptide Sequence MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
Product Format Liquid or Lyophilized powder
Reference Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987)
Description of Target Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230).
Reconstitution and Storage -20°C or -80°C
Protein Sequence MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
Datasheets/Manuals Printable datasheet for E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) (OPCA02947)
Additional Information Protein Description: Full length
Subcellular Location: Host cytoplasm, Host nucleus
Storage Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Uniprot ID P06788
Protein Name Protein E7
Purification Affinity purified using IMAC
Gene Symbol E7
Predicted Species Reactivity Human papillomavirus type 18|Human Papillomavirus Type 18
Image 1
Protein SDS-PAGE
E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) in SDS-PAGE showing the molecular weight of approximately 14 kDa.
 

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