Product Number |
OPCA02947 |
Product Page |
www.avivasysbio.com/e7-recombinant-protein-human-papillomavirus-type-18-opca02947.html |
Name |
E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) |
Protein Size (# AA) |
Recombinant amino acids |
Molecular Weight |
14 kDa |
Tag |
N-terminal 6xHis-tagged |
Host |
Human |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Concentration |
Varies by lot. See vial for exact concentration. |
Source |
Yeast |
Protein Range |
1-105 aa |
Alias Symbols |
E7Protein E7 |
Peptide Sequence |
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ |
Product Format |
Liquid or Lyophilized powder |
Reference |
Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987) |
Description of Target |
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230). |
Reconstitution and Storage |
-20°C or -80°C |
Protein Sequence |
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ |
Datasheets/Manuals |
Printable datasheet for E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) (OPCA02947) |
Additional Information |
Protein Description: Full length Subcellular Location: Host cytoplasm, Host nucleus |
Storage Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Uniprot ID |
P06788 |
Protein Name |
Protein E7 |
Purification |
Affinity purified using IMAC |
Gene Symbol |
E7 |
Predicted Species Reactivity |
Human papillomavirus type 18|Human Papillomavirus Type 18 |
Image 1 | Protein SDS-PAGE
| E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) in SDS-PAGE showing the molecular weight of approximately 14 kDa. |
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