Amyloid Beta Peptide 1-42 (OVA - Conjugated) (OOCD00250)

• Product Number: OOCD00250
• Name: Amyloid Beta Peptide 1-42 (OVA - Conjugated) (OOCD00250)
• Molecular Weight: 111.2 Da
• Tag: N-terminal His Tag
• Conjugation: Ovalbumin
• NCBI Gene Id: 351
• Purity: > 90%
• Gene Full Name: amyloid beta precursor protein
• Alias Symbols: AAA;ABETA;ABPP;AD1;alpha-sAPP;alzheimer disease amyloid protein;amyloid beta (A4) precursor protein;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta precursor protein;APPI;beta-amyloid peptide;beta-amyloid peptide(1-40);beta-amyloid peptide(1-42);beta-amyloid precursor protein;cerebral vascular amyloid peptide;CTFgamma;CVAP;peptidase nexin-II;PN2;PN-II;preA4;protease nexin-II;testicular tissue protein Li 2.
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Description of Target: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Additional Information: PubChem: Ab1-42
• Additional Information: Chemical Formula: C5H9N3
• Formulation: PBS, pH7.4.
• Uniprot ID: P05067
• Protein Name: Amyloid-beta A4 protein
• Gene Symbol: APP
• Predicted Species Reactivity: Homo sapiens|Human
• Application: High-performance liquid chromatography|Mass spectrometry|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot