| Product Number |
OERA00071 |
| Product Page |
www.avivasysbio.com/idn3-control-peptide-oera00071.html |
| Name |
IDN3 CONTROL PEPTIDE (OERA00071) |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
25836 |
| Concentration |
1 mg/ml |
| Gene Full Name |
NIPBL cohesin loading factor |
| Alias Symbols |
CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog. |
| Product Format |
Liquid (sterile filtered) |
| Description of Target |
Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). |
| Reconstitution and Storage |
2°C to 8°C|-20°C |
| Datasheets/Manuals |
Printable datasheet for IDN3 CONTROL PEPTIDE (OERA00071) |
| Uniprot ID |
Q6KC79 |
| Protein Name |
Nipped-B-like protein |
| Gene Symbol |
NIPBL |
| Predicted Species Reactivity |
Homo sapiens|Human |
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