| Product Number |
OASG07577 |
| Product Page |
www.avivasysbio.com/wipf1-antibody-c-terminal-region-oasg07577.html |
| Name |
WIPF1 Antibody - C-terminal region (OASG07577) |
| Molecular Weight |
52 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
7456; 215280; 117538 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
WAS/WASL interacting protein family, member 1 |
| Alias Symbols |
WIP, WAS2, PRPL-2, WASPIP |
| Product Format |
Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Reconstitution and Storage |
Store at -20C. Avoid repeated freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-WIPF1 (OASG07577) antibody |
| Specificity |
WIP Polyclonal Antibody detects endogenous levels of WIP protein. |
| Additional Information |
Function: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Cellular Location: Cytoplasmic vesicle / Cytoplasm > cytoskeleton / Cell projection > ruffle.
Tissue Location: Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
Sequence and Domain Family: Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site. / Belongs to the verprolin family. / Contains 1 WH2 domain.
|
| Application Info |
WB 1:500~2000
IHC 1:100~300
ELISA 1:5000
|
| Immunogen |
Synthesized peptide derived at 390-470 amino acids from the C-terminal region of human WIP. |
| Intended Use |
For research use only. |
| Uniprot ID |
O43516, Q8K1I7, Q6IN36 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
WIPF1 |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
WB, IHC |
| Image 1 | |
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