| Product Number |
OASG05505 |
| Product Page |
www.avivasysbio.com/ep300-antibody-phospho-ser89-oasg05505.html |
| Name |
EP300 Antibody (Phospho-Ser89) (OASG05505) |
| Molecular Weight |
260 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
2033; |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
E1A binding protein p300 |
| Alias Symbols |
p300, KAT3B, MKHK2, RSTS2 |
| Product Format |
Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Description of Target |
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. |
| Reconstitution and Storage |
Store at -20C. Avoid repeated freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-EP300 (OASG05505) antibody |
| Specificity |
Phospho-p300 (S89) Polyclonal Antibody detects endogenous levels of p300 protein only when phosphorylated at S89. |
| Application Info |
IHC 1:100-1:300; ELISA 1:5000; |
| Immunogen |
Synthesized peptide derived from human p300 around the phosphorylation site of S89. Location: 30-110aa. |
| Uniprot ID |
Q09472, B2RWS6 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Target Post-Translational Modification |
Phospho-Ser89 |
| Gene Symbol |
EP300 |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
IHC |
| Image 1 | |
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