BCL2L1 Antibody (Phospho-Ser62) (OASG00744)

Data Sheet
 
Product Number OASG00744
Product Page www.avivasysbio.com/bcl2l1-antibody-phospho-ser62-oasg00744.html
Name BCL2L1 Antibody (Phospho-Ser62) (OASG00744)
Molecular Weight 24 kDa
Isotype IgG
NCBI Gene Id 598; 12048; 24888
Host Rabbit
Clonality Polyclonal
Concentration 1 mg/ml
Gene Full Name BCL2-like 1
Alias Symbols BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S
Product Format Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Description of Target The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Reconstitution and Storage Store at -20C. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals Printable datasheet for anti-BCL2L1 (OASG00744) antibody
Specificity Phospho-Bcl-x (S62) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at S62.
Application Info WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Immunogen Synthesized peptide derived from human Bcl-x around the phosphorylation site of S62. Location: 40-120aa.
Uniprot ID Q07817, Q64373, P53563
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Target Post-Translational Modification Phospho-Ser62
Gene Symbol BCL2L1
Predicted Species Reactivity Human, Mouse, Rat
Application WB, IHC
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