Product Number |
OASG00744 |
Product Page |
www.avivasysbio.com/bcl2l1-antibody-phospho-ser62-oasg00744.html |
Name |
BCL2L1 Antibody (Phospho-Ser62) (OASG00744) |
Molecular Weight |
24 kDa |
Isotype |
IgG |
NCBI Gene Id |
598; 12048; 24888 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Gene Full Name |
BCL2-like 1 |
Alias Symbols |
BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S |
Product Format |
Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Description of Target |
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
Reconstitution and Storage |
Store at -20C. Avoid repeated freeze/thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-BCL2L1 (OASG00744) antibody |
Specificity |
Phospho-Bcl-x (S62) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at S62. |
Application Info |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; |
Immunogen |
Synthesized peptide derived from human Bcl-x around the phosphorylation site of S62. Location: 40-120aa. |
Uniprot ID |
Q07817, Q64373, P53563 |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Target Post-Translational Modification |
Phospho-Ser62 |
Gene Symbol |
BCL2L1 |
Predicted Species Reactivity |
Human, Mouse, Rat |
Application |
WB, IHC |
Image 1 | |
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