ACE2 Antibody - middle region (OASG00144)

Data Sheet
Product Number OASG00144
Product Page
Name ACE2 Antibody - middle region (OASG00144)
Molecular Weight 90 kDa
Isotype IgG
Conjugation Unconjugated
NCBI Gene Id 59272; 70008;
Host Rabbit
Clonality Polyclonal
Concentration 1 mg/ml
Gene Full Name angiotensin I converting enzyme 2
Alias Symbols ACEH
Product Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Description of Target Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.
Reconstitution and Storage Store at -20°C. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ACE2 (OASG00144) antibody
Specificity ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein.
Additional Information Cellular Localization: Processed angiotensin-converting enzyme 2: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Detected in both cell membrane and cytoplasm in neurons.
Tissue Specificity: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
Application Info WB: 1:500-1:2000
ELISA: 1:40,000
Optimal dilutions should be determined by the end user.
Immunogen Synthesized peptide derived from the Internal region of human ACE2.
Uniprot ID Q9BYF1, Q8R0I0

Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons. Int J Mol Sci. 22, (2020). 33375653

Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus. Cell Mol Neurobiol. NULL, NULL (2020). 32623546

Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Target Post-Translational Modification N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.
Gene Symbol ACE2
Predicted Species Reactivity Human, Mouse
Application WB, ELISA
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