| Product Number |
OASB02639 |
| Product Page |
www.avivasysbio.com/mouse-anti-human-cd105c-antibody-apc-oasb02639.html |
| Name |
Human CD105C Antibody : APC (OASB02639) |
| Conjugation |
APC |
| NCBI Gene Id |
2022; 100070421 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Concentration |
Lot specific |
| Gene Full Name |
endoglin |
| Alias Symbols |
END, HHT1, ORW1 |
| Product Format |
Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer |
| Description of Target |
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Reconstitution and Storage |
Store at 2-8C |
| Datasheets/Manuals |
Printable datasheet for Human CD105C Antibody : APC (OASB02639) |
| Specificity |
CD105 |
| Additional Information |
Description: CD105, also known as endoglin, is a 90 kDa type II transmembrane glycoprotein that is expressed on the cell surface as a disulfide-linked homodimer and is found on endothelial cells. CD105 is one of several receptors for the various isoforms of TGFbeta which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control on the immune response. |
| Immunogen |
Antigen preparation isolated from cell membranes of leukemia cells derived from a patient with non-T/non-B-cell acute lymphoblastic leukemia (ALL) |
| Uniprot ID |
P17813, U3MI26 |
| Protein Name |
endoglin |
| Protein Accession # |
NP_000109.1? |
| Nucleotide Accession # |
NM_000118.3 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ENG, ENG |
| Predicted Species Reactivity |
Human |
| Application |
FC |
| Image 1 | Human histiocytic lymphoma cell line U-937
 | Human histiocytic lymphoma cell line U-937 was stained with Mouse Anti-Human CD105-APC. |
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