APOLIPOPROTEIN E Antibody (OASA11404)

Data Sheet
 
Product Number OASA11404
Product Page www.avivasysbio.com/apolipoprotein-e-antibody-oasa11404.html
Name APOLIPOPROTEIN E Antibody (OASA11404)
Isotype IgG1
NCBI Gene Id 348
Host Mouse
Clonality Monoclonal
Concentration 1 mg/ml
Alias Symbols AD2, LPG, APO-E, ApoE4, LDLCQ5
Product Format Liquid. Phosphate buffered saline
Reconstitution and Storage -20°C
Datasheets/Manuals Printable datasheet for APOLIPOPROTEIN E Antibody (OASA11404)
Specificity OASA11404 specifically recognises an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents.
Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB,E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype.
Clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB,E cell receptor, see Krul, E.S et al for details. Aviva recommends the use of OASA11403 for functional studies.
Additional Information Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Preservative Stabilisers: 0.09% Sodium Azide (NaN3)
Additional Information Buffer Solutions: Phosphate buffered saline
Application Info Western Blotting: OASA11404 detects a major band of approximately 34-36kDa in human liver cell lysates.
ELISA: 1/100 - 1/1000
Immunogen Purified ApoHDL fraction.
Uniprot ID P02649
Protein Name Apolipoprotein E
Protein Accession # NP_000032.1
Purification Protein G Purified
Predicted Species Reactivity Human
Application Enzyme-linked immunosorbent assay|Western blot
Predicted Homology Based on Immunogen Sequence Human
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