| Product Number |
OAPB00559 |
| Product Page |
www.avivasysbio.com/ptk7-antibody-oapb00559.html |
| Name |
PTK7 Antibody (OAPB00559) |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
5754 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 mg/ml |
| Gene Full Name |
protein tyrosine kinase 7 (inactive) |
| Alias Symbols |
CCK4;CCK-4;colon carcinoma kinase 4;inactive tyrosine-protein kinase 7;Protein-tyrosine kinase 7;pseudo tyrosine kinase receptor 7;PTK7 protein tyrosine kinase 7;tyrosine-protein kinase-like 7. |
| Product Format |
Liquid. PTK7 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Reference |
Park SK, Lee HS and Lee ST. Characterization of the human full-length PTK7 cDNA encoding a receptor protein kinase-like molecule closely related to chick KLG. J. Biochem.1996; 119:235-9.;Lu X, Borchers AG, Jolicoeur C, et al. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature2004; 430:93-8.;Easty DJ, Mitchell PJ, Patel K, et al. Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. Int. J. Cancer1997; 1061-5.;Muller-Tidow C, Schwable J, Steffen B, et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin. Cancer Res.2004; 10:1241-9. |
| Description of Target |
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Reconstitution and Storage |
PTK7 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Datasheets/Manuals |
Printable datasheet for PTK7 Antibody (OAPB00559) (OAPB00559) |
| Additional Information |
Buffer: Antibody is supplied in PBS containing 0.02% sodium azide. |
| Application Info |
PTK7 antibody can be used for detection of PTK7 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user) |
| Blocking Peptide |
For anti-PTK7 antibody is Catalog # OEPB02690 |
| Immunogen |
PTK7 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human PTK7. The immunogen is located within amino acids 880 - 930 of PTK7. |
| Uniprot ID |
Q13308 |
| Protein Name |
Inactive tyrosine-protein kinase 7|PTK7 protein tyrosine kinase 7 [Homo sapiens] |
| Protein Accession # |
https://www.ncbi.nlm.nih.gov/protein/AAH71557 |
| Purification |
Affinity Purified |
| Gene Symbol |
PTK7 |
| Predicted Species Reactivity |
Chicken|Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot |
| Predicted Homology Based on Immunogen Sequence |
Human; Mouse; Rat |
| Image 1 | human colon, mouse kidney and Rat liver
 | Western blot analysis of PTK7 in (A) human colon, (B) mouse kidney and (C) rat liver tissue lysate with PTK7 antibody at 1 ug/mL. |
|
| Image 2 | human colon
 | Immunohistochemistry of PTK7 in human colon tissue with PTK7 antibody at 2.5 ug/mL. |
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