| Product Number |
OAEE01081 |
| Product Page |
www.avivasysbio.com/cd74-antibody-oaee01081.html |
| Name |
CD74 Antibody (OAEE01081) |
| Clone |
M5/114 |
| Isotype |
IgG2b |
| Conjugation |
FITC |
| NCBI Gene Id |
972 |
| Host |
Rat |
| Clonality |
Monoclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
HLA class II histocompatibility antigen gamma chain |
| Alias Symbols |
II, p33, DHLAG, HLADG, Ia-GAMMA |
| Product Format |
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Reference |
Clausen BE, Waldburger JM, Schwenk F, Barras E, Mach B, Rajewsky K, Förster I, Reith W: Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity. 1998 Feb;8(2):143-55.
Zang W, Kalache S, Lin M, Schroppel B, Murphy B: MHC Class II-mediated apoptosis by a nonpolymorphic MHC Class II peptide proceeds by activation of protein kinase C. J Am Soc Nephrol. 2005 Dec;16(12):3661-8.
Kuwano Y, Prazma CM, Yazawa N, Watanabe R, Ishiura N, Kumanogoh A, Okochi H, Tamaki K, Fujimoto M, Tedder TF: CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. Int Immunol. 2007 Aug;19(8):977-92.
Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P, Rudensky AY: Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. J Immunol. 2005 Feb 1;174(3):1205-12.
Kleijmeer M, Ramm G, Schuurhuis D, Griffith J, Rescigno M, Ricciardi-Castagnoli P, Rudensky AY, Ossendorp F, Melief CJ, Stoorvogel W, Geuze HJ: Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol. 2001 Oct 1;155(1):53-63.
De Souza Leao S, Lang T, Prina E, Hellio R, Antoine JC: Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells. J Cell Sci. 1995 Oct;108 ( Pt 10):3219-31.
Viville S, Neefjes J, Lotteau V, Dierich A, Lemeur M, Ploegh H, Benoist C, Mathis D: Mice lacking the MHC class II-associated invariant chain. Cell. 1993 Feb 26;72(4):635-48.
Bhattacharya A, Dorf ME, Springer TA: A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol. 1981 Dec;127(6):2488-95.
|
| Reconstitution and Storage |
2°C to 8°C |
| Datasheets/Manuals |
Printable datasheet for CD74 Antibody (OAEE01081) (OAEE01081) |
| Specificity |
The rat monoclonal antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes. |
| Immunogen |
Activated C57BL/6 mouse spleen cells |
| Formulation |
FITC |
| Storage Buffer |
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Uniprot ID |
P04233 |
| Protein Name |
HLA class II histocompatibility antigen gamma chain |
| Protein Accession # |
NP_001020329.1; NP_001020330.1; NP_004346.1 |
| Purification |
Purified by size-exclusion chromatography |
| Nucleotide Accession # |
NM_001025158.2; NM_001025159.2; NM_004355.3 |
| Gene Symbol |
CD74 |
| Predicted Species Reactivity |
Mouse |
| Application |
Flow cytometry |
| Image 1 | |
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