NGFR Antibody (OAEE00173)

• Product Number: OAEE00173
• Name: NGFR Antibody (OAEE00173)
• Clone: NGFR5
• Isotype: IgG1
• NCBI Gene Id: 4804
• Host: Mouse
• Clonality: Monoclonal
• Purity: > 95% (by SDS-PAGE)
• Concentration: 1 mg/ml
• Gene Full Name: nerve growth factor receptor
• Alias Symbols: CD271;Gp80-LNGFR;low affinity neurotrophin receptor p75NTR;low-affinity nerve growth factor receptor;NGF receptor;p75 ICD;p75(NTR);p75NTR;TNFR superfamily, member 16;TNFRSF16;tumor necrosis factor receptor superfamily member 16.
• Product Format: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Reference: Alpers CE, Hudkins KL, Ferguson M, Johnson RJ, Schatteman GC, Bothwell M: Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys. Lab Invest. 1993 Dec;69(6):703-13.
  Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci. 1988 Mar;8(3):860-73.
  Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci. 1988 Mar;8(3):860-73.
  Marano N, Dietzschold B, Earley JJ Jr, Schatteman G, Thompson S, Grob P, Ross AH, Bothwell M, Atkinson BF, Koprowski H: Purification and amino terminal sequencing of human melanoma nerve growth factor receptor. J Neurochem. 1987 Jan;48(1):225-32.
  Thompson SJ, Schatteman GC, Gown AM, Bothwell M: A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. Am J Clin Pathol. 1989 Oct;92(4):415-23.
  
• Description of Target: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
• Reconstitution and Storage: 2°C to 8°C
• Specificity: The mouse monoclonal antibody NGFR5 (originally C34C) recognizes CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160.
• Immunogen: Purified CD271 protein isolated from human melanoma cell line A875
• Formulation: Purified
• Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Uniprot ID: P08138
• Protein Name: Tumor necrosis factor receptor superfamily member 16
• Protein Accession #: NP_002498.1
• Purification: Purified
• Nucleotide Accession #: NM_002507.3
• Gene Symbol: NGFR
• Predicted Species Reactivity: Cat|Ferret|Human|Non-human Primate|Rabbit
• Application: Flow cytometry|Immunocytochemistry|Immunohistochemistry-Paraffin|Immunoprecipitation|Mass cytometry|Western blot
• Image 1: Brain tumor cells
  
  Surface staining (mass cytometry) of brain tumor cells with anti-CD271 (NGFR5) 143Nd. Gated on singlets.