Product Number |
OAED00105 |
Product Page |
www.avivasysbio.com/mapk14-antibody-oaed00105.html |
Name |
MAPK14 Antibody (OAED00105) |
NCBI Gene Id |
1432 |
Host |
Rabbit |
Clonality |
Polyclonal |
Gene Full Name |
Mitogen-activated protein kinase 14 |
Alias Symbols |
RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA |
Description of Target |
Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance. |
Reconstitution and Storage |
Long Term Storage : -20C
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Datasheets/Manuals |
Printable datasheet for anti-MAPK14 (OAED00105) antibody |
Specificity |
Recognizes human, mouse, rat, bovine, dog, chicken, guinea pig, hamster, monkey, pig, rabbit and sheep p38. Detects a band of ~38kDa by Western blot. |
Application Info |
Immunohistochemistry (paraffin sections) Immunoprecipitation (1:500) Western Blot (1:10,000, ECL) Optimal conditions must be determined individually for each application. |
Immunogen |
Synthetic peptide corresponding to a portion of human p38. The sequence is completely conserved in mouse. |
Formulation |
Liquid. Whole rabbit serum. |
Uniprot ID |
Q16539 |
Protein Name |
Mitogen-activated protein kinase 14 |
Protein Accession # |
NP_001306.1; NP_620581.1; NP_620582.1; NP_620583.1 |
Nucleotide Accession # |
NM_001315.2; NM_139012.2; NM_139013.2; NM_139014.2 |
Gene Symbol |
MAPK14 |
Predicted Species Reactivity |
Human, Mouse, Rat, Bovine, Dog, Chicken, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep |
Application |
IHC, IP, WB |
Image 1 | Human placenta tissue
| IHC Analysis: Human placenta tissue stained with p38 MAPK, pAb at 10 ug/ml. |
| Image 2 | Human spleen tissue
| IHC Analysis: Human spleen tissue stained with p38 MAPK, pAb at 10 ug/ml. |
| Image 3 | Human tonsil tissue
| IHC Analysis: Human tonsil tissue stained with p38 MAPK, pAb at 10 ug/ml. |
| Image 4 | HeLa, Brain
| Western Blot analysis of p38 MAPK: Lane 1: MW Marker; Lane 2: HeLa, (Cell Lysate); Lane 3: Brain (mouse), (tissue extract); Lane 4: Brain (rat), (tissue extract). |
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