MAPK14 Antibody (OAED00105)

Data Sheet
 
Product Number OAED00105
Product Page www.avivasysbio.com/mapk14-antibody-oaed00105.html
Name MAPK14 Antibody (OAED00105)
NCBI Gene Id 1432
Host Rabbit
Clonality Polyclonal
Gene Full Name Mitogen-activated protein kinase 14
Alias Symbols RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
Description of Target Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.
Reconstitution and Storage Long Term Storage : -20C
Datasheets/Manuals Printable datasheet for anti-MAPK14 (OAED00105) antibody
Specificity Recognizes human, mouse, rat, bovine, dog, chicken, guinea pig, hamster, monkey, pig, rabbit and sheep p38. Detects a band of ~38kDa by Western blot.
Application Info Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:500)
Western Blot (1:10,000, ECL)
Optimal conditions must be determined individually for each application.
Immunogen Synthetic peptide corresponding to a portion of human p38. The sequence is completely conserved in mouse.
Formulation Liquid. Whole rabbit serum.
Uniprot ID Q16539
Protein Name Mitogen-activated protein kinase 14
Protein Accession # NP_001306.1; NP_620581.1; NP_620582.1; NP_620583.1
Nucleotide Accession # NM_001315.2; NM_139012.2; NM_139013.2; NM_139014.2
Gene Symbol MAPK14
Predicted Species Reactivity Human, Mouse, Rat, Bovine, Dog, Chicken, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep
Application IHC, IP, WB
Image 1
Human placenta tissue
IHC Analysis: Human placenta tissue stained with p38 MAPK, pAb at 10 ug/ml.
Image 2
Human spleen tissue
IHC Analysis: Human spleen tissue stained with p38 MAPK, pAb at 10 ug/ml.
Image 3
Human tonsil tissue
IHC Analysis: Human tonsil tissue stained with p38 MAPK, pAb at 10 ug/ml.
Image 4
HeLa, Brain
Western Blot analysis of p38 MAPK: Lane 1: MW Marker; Lane 2: HeLa, (Cell Lysate); Lane 3: Brain (mouse), (tissue extract); Lane 4: Brain (rat), (tissue extract).
 

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