DAPK3 Antibody (OACD01026)

Data Sheet
 
Product Number OACD01026
Product Page www.avivasysbio.com/dapk3-antibody-oacd01026.html
Name DAPK3 Antibody (OACD01026)
Molecular Weight 51 kDa
Isotype IgG
NCBI Gene Id 13144
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name death-associated protein kinase 3
Alias Symbols DAP kinase 3;DAP-like kinase;death-associated kinase 3;death-associated protein kinase 3;dlk;MYPT1 kinase;ZIPK;ZIP-kinase.
Product Format Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description of Target Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis (By similarity). Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.
Reconstitution and Storage 2°C to 8°C|-20°C
Datasheets/Manuals Printable datasheet for DAPK3 Antibody (OACD01026)
Specificity The antibody is a rabbit polyclonal antibody raised against DAPK3. It has been selected for its ability to recognize DAPK3 in immunohistochemical staining and western blotting.
Immunogen Range: Met1 - Arg448
Formulation PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Uniprot ID O54784
Protein Name Death-associated protein kinase 3
Protein Accession # NP_001177402.1
Purification Affinity Purified; Protein A Purified
Application Data Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
Optimal working dilutions must be determined by end user.
Nucleotide Accession # NM_001190473
Preservative 0.02% NaN3
Gene Symbol Dapk3
Predicted Species Reactivity Mouse|Rat
Application Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Image 1
Death-associated protein kinase 3
Western Blot with Mouse Recombinant Death-associated protein kinase 3
 

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