| Product Number |
OACA09697 |
| Product Page |
www.avivasysbio.com/ehd3-antibody-oaca09697.html |
| Name |
EHD3 Antibody (OACA09697) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
30845 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purity |
>95% |
| Gene Full Name |
EH domain containing 3 |
| Alias Symbols |
EH domain-containing protein 3;PAST homolog 3;PAST3. |
| Product Format |
Liquid |
| Description of Target |
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for EHD3 Antibody (OACA09697) (OACA09697) |
| Immunogen |
Recombinant Human EH domain-containing protein 3 protein (269-498AA) |
| Formulation |
50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
Q9NZN3 |
| Protein Name |
EH domain-containing protein 3 |
| Protein Accession # |
NP_055415 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_014600 |
| Preservative |
0.03% Proclin 300 |
| Gene Symbol |
EHD3 |
| Predicted Species Reactivity |
Human |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry |
| Image 1 | Human brain tissue
 | Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100 |
| | Image 2 | Human kidney tissue
 | Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100 |
| | Image 3 | HepG2 cells
 | Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) |
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