| Product Number |
OACA09411 |
| Product Page |
www.avivasysbio.com/lats1-antibody-oaca09411.html |
| Name |
LATS1 Antibody (OACA09411) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
9113 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purity |
>95% |
| Gene Full Name |
large tumor suppressor kinase 1 |
| Alias Symbols |
h-warts;large tumor suppressor homolog 1;LATS (large tumor suppressor, Drosophila) homolog 1;LATS, large tumor suppressor, homolog 1;serine/threonine-protein kinase LATS1;WARTS;WARTS protein kinase;wts. |
| Product Format |
Liquid |
| Description of Target |
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for LATS1 Antibody (OACA09411) (OACA09411) |
| Immunogen |
Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA) |
| Formulation |
50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
O95835 |
| Protein Name |
Serine/threonine-protein kinase LATS1 |
| Protein Accession # |
NP_001257448 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_001270519 |
| Preservative |
0.03% Proclin 300 |
| Gene Symbol |
LATS1 |
| Predicted Species Reactivity |
Human |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunoprecipitation |
| Image 1 | Human liver cancer
 | Immunohistochemistry of paraffin-embedded human liver cancer at dilution of 1:100 |
| | Image 2 | Human placenta tissue
 | Immunohistochemistry of paraffin-embedded human placenta tissue at dilution of 1:100 |
| | Image 3 | HeLa cells
 | Immunofluorescent analysis of HeLa cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) |
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