NPRL2 Antibody (OACA06783)

Data Sheet
 
Product Number OACA06783
Product Page www.avivasysbio.com/nprl2-antibody-oaca06783.html
Name NPRL2 Antibody (OACA06783)
Isotype IgG
Conjugation Unconjugated
NCBI Gene Id 10641
Host Rabbit
Clonality Polyclonal
Gene Full Name NPR2 like, GATOR1 complex subunit
Alias Symbols 2810446G01Rik;FFEVF2;G21 protein;GATOR complex protein NPRL2;gene 21 protein;homologous to yeast nitrogen permease (candidate tumor suppressor);nitrogen permease regulator 2-like protein;NPR2;NPR2L;NPR2-like protein;tumor suppressor candidate 4;TUSC4.
Product Format Liquid
Reference [1]A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.Science 340:1100-1106(2013). [2]A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex."Neklesa T.K., Davis R.W.PLoS Genet. 5:E1000515-E1000515(2009). [3]TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling."Kurata A., Katayama R., Watanabe T., Tsuruo T., Fujita N.Cancer Sci. 99:1827-1834(2008)
Description of Target As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Reconstitution and Storage -20°C or -80°C
Datasheets/Manuals Printable datasheet for NPRL2 Antibody (OACA06783) (OACA06783)
Immunogen Recombinant Human Nitrogen permease regulator 2-like protein (1-220AA)
Formulation PBS with, 50% glycerol, pH7.3.
Uniprot ID Q8WTW4
Protein Name GATOR complex protein NPRL2
Protein Accession # NP_006536
Purification Affinity Purified
Nucleotide Accession # NM_006545
Preservative 0.02% sodium azide
Gene Symbol NPRL2
Predicted Species Reactivity Human|Mouse
Application Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
Image 1
Mouse skeletal muscle tissue
All lanes: Nitrogen permease regulator 2-like protein antibody at 7ug/ml+mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 44,24 kDa
Observed band size: 44 kDa
Image 2
Human lung cancer
Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100
Image 3
Human rectum
Immunohistochemistry of paraffin-embedded human rectum at dilution 1:100
 

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