| Product Number |
OACA06447 |
| Product Page |
www.avivasysbio.com/snx6-antibody-oaca06447.html |
| Name |
SNX6 Antibody (OACA06447) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
58533 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
sorting nexin 6 |
| Alias Symbols |
MSTP010;sorting nexin-6;TFAF2;TRAF4-associated factor 2;tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2. |
| Product Format |
Liquid |
| Description of Target |
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for SNX6 Antibody (OACA06447) (OACA06447) |
| Immunogen |
Recombinant Human Sorting nexin-6 protein (1-290AA) |
| Formulation |
50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
Q9UNH7 |
| Protein Name |
Sorting nexin-6 |
| Protein Accession # |
NP_067072 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_021249 |
| Preservative |
0.03% Proclin 300 |
| Gene Symbol |
SNX6 |
| Predicted Species Reactivity |
Human |
| Application |
Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot |
| Image 1 | Hela whole cell lysate
 | Western blot
All lanes: SNX6 antibody at 4ug/ml+ Hela whole cell lysate
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 47,34 kDa
Observed band size: 47 kDa
|
| | Image 2 | Human small intestine tissue
 | Immunohistochemistry of paraffin-embedded human small intestine tissue at dilution of 1:100 |
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