Product Number |
OACA01949 |
Product Page |
www.avivasysbio.com/ager-antibody-fitc-conjugated-oaca01949.html |
Name |
AGER Antibody - FITC Conjugated (OACA01949) |
Isotype |
IgG |
Conjugation |
FITC |
NCBI Gene Id |
177 |
Host |
Rabbit |
Clonality |
Polyclonal |
Purity |
>95% |
Concentration |
Varies by lot. See vial for exact concentration. |
Gene Full Name |
advanced glycosylation end-product specific receptor |
Alias Symbols |
advanced glycosylation end product-specific receptor;RAGE;receptor for advanced glycation end-products variant 20;Receptor for advanced glycosylation end products;SCARJ1;sRAGE. |
Product Format |
Liquid |
Reference |
[1] Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.'Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.C., Elliston K., Stern D., Shaw A.J. Biol. Chem. 267:14998-15004(1992) [2] Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.'Sugaya K., Fukagawa T., Matsumoto K., Mita K., Takahashi E., Ando A., Inoko H., Ikemura T.Genomics 23:408-419(1994) [3] Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.'Yonekura H., Yamamoto Y., Sakurai S., Petrova R.G., Abedin J., Li H., Yasui K., Takeuchi M., Makita Z., Takasawa S., Okamoto H., Watanabe T., Yamamoto H.Biochem. J. 370:1097-1109(2003) |
Description of Target |
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. |
Reconstitution and Storage |
-20°C or -80°C |
Datasheets/Manuals |
Printable datasheet for AGER Antibody - FITC Conjugated (OACA01949) (OACA01949) |
Immunogen |
Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) |
Uniprot ID |
Q15109 |
Protein Name |
Advanced glycosylation end product-specific receptor |
Purification |
Protein G Purified |
Gene Symbol |
AGER |
Predicted Species Reactivity |
Human |
Application |
WB, IHC |
Image 1 | |
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