AGER Antibody - FITC Conjugated (OACA01949)

Data Sheet
 
Product Number OACA01949
Product Page www.avivasysbio.com/ager-antibody-fitc-conjugated-oaca01949.html
Name AGER Antibody - FITC Conjugated (OACA01949)
Isotype IgG
Conjugation FITC
NCBI Gene Id 177
Host Rabbit
Clonality Polyclonal
Purity >95%
Concentration Varies by lot. See vial for exact concentration.
Gene Full Name advanced glycosylation end-product specific receptor
Alias Symbols advanced glycosylation end product-specific receptor;RAGE;receptor for advanced glycation end-products variant 20;Receptor for advanced glycosylation end products;SCARJ1;sRAGE.
Product Format Liquid
Reference [1] Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.'Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.C., Elliston K., Stern D., Shaw A.J. Biol. Chem. 267:14998-15004(1992)
[2] Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.'Sugaya K., Fukagawa T., Matsumoto K., Mita K., Takahashi E., Ando A., Inoko H., Ikemura T.Genomics 23:408-419(1994)
[3] Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.'Yonekura H., Yamamoto Y., Sakurai S., Petrova R.G., Abedin J., Li H., Yasui K., Takeuchi M., Makita Z., Takasawa S., Okamoto H., Watanabe T., Yamamoto H.Biochem. J. 370:1097-1109(2003)
Description of Target Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Reconstitution and Storage -20°C or -80°C
Datasheets/Manuals Printable datasheet for AGER Antibody - FITC Conjugated (OACA01949) (OACA01949)
Immunogen Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA)
Uniprot ID Q15109
Protein Name Advanced glycosylation end product-specific receptor
Purification Protein G Purified
Gene Symbol AGER
Predicted Species Reactivity Human
Application WB, IHC
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