Product Number |
OACA01930 |
Product Page |
www.avivasysbio.com/kras-antibody-fitc-conjugated-oaca01930.html |
Name |
KRAS Antibody - FITC Conjugated (OACA01930) |
Isotype |
IgG |
Conjugation |
FITC |
NCBI Gene Id |
3845 |
Host |
Rabbit |
Clonality |
Polyclonal |
Purity |
> 95% |
Concentration |
Varies by lot. See vial for exact concentration. |
Gene Full Name |
KRAS proto-oncogene, GTPase |
Description |
|
Alias Symbols |
cellular c-Ki-ras2 proto-oncogene, cellular transforming proto-oncogene, CFC2, c-Ki-ras, c-Ki-ras2, c-Kirsten-ras protein, C-K-RAS, C-K-RAS, GTPase KRas, KI-RAS, Kirsten rat sarcoma viral oncogene homolog, Kirsten rat sarcoma viral proto-oncogene, K-Ras |
Product Format |
Liquid |
Reference |
[1] Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.'McGrath J.P., Capon D.J., Smith D.H., Chen E.Y., Seeburg P.H., Goeddel D.V., Levinson A.D.Nature 304:501-506(1983) [2] Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.'Shimizu K., Birnbaum D., Ruley M.A., Fasano O., Suard Y., Edlund L., Taparowsky E., Goldfarb M., Wigler M.Nature 304:497-500(1983) [3] Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.'Capon D.J., Seeburg P.H., McGrath J.P., Hayflick J.S., Edman U., Levinson A.D., Goeddel D.V.Nature 304:507-513(1983) |
Description of Target |
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). |
Reconstitution and Storage |
-20°C or -80°C |
Datasheets/Manuals |
Printable datasheet for KRAS Antibody - FITC Conjugated (OACA01930) (OACA01930) |
Immunogen |
Recombinant Human GTPase KRas protein (2-168AA) |
Uniprot ID |
P01116 |
Protein Name |
GTPase KRas |
Publications |
Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS. J Clin Med. 8, (2019). 31635338 |
Protein Accession # |
NP_004976.2; NP_203524.1; XP_006719132.1 |
Purification |
Protein G Purified |
Nucleotide Accession # |
NM_004985.4; NM_033360.3; XM_006719069.2 |
Gene Symbol |
KRAS |
Predicted Species Reactivity |
Human |
Application |
WB |
Image 1 | |
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