KRAS Antibody - FITC Conjugated (OACA01930)

Data Sheet
 
Product Number OACA01930
Product Page www.avivasysbio.com/kras-antibody-fitc-conjugated-oaca01930.html
Name KRAS Antibody - FITC Conjugated (OACA01930)
Isotype IgG
Conjugation FITC
NCBI Gene Id 3845
Host Rabbit
Clonality Polyclonal
Purity > 95%
Concentration Varies by lot. See vial for exact concentration.
Gene Full Name KRAS proto-oncogene, GTPase
Description
Alias Symbols cellular c-Ki-ras2 proto-oncogene, cellular transforming proto-oncogene, CFC2, c-Ki-ras, c-Ki-ras2, c-Kirsten-ras protein, C-K-RAS, C-K-RAS, GTPase KRas, KI-RAS, Kirsten rat sarcoma viral oncogene homolog, Kirsten rat sarcoma viral proto-oncogene, K-Ras
Product Format Liquid
Reference [1] Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.'McGrath J.P., Capon D.J., Smith D.H., Chen E.Y., Seeburg P.H., Goeddel D.V., Levinson A.D.Nature 304:501-506(1983)
[2] Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.'Shimizu K., Birnbaum D., Ruley M.A., Fasano O., Suard Y., Edlund L., Taparowsky E., Goldfarb M., Wigler M.Nature 304:497-500(1983)
[3] Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.'Capon D.J., Seeburg P.H., McGrath J.P., Hayflick J.S., Edman U., Levinson A.D., Goeddel D.V.Nature 304:507-513(1983)
Description of Target Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).
Reconstitution and Storage -20°C or -80°C
Datasheets/Manuals Printable datasheet for KRAS Antibody - FITC Conjugated (OACA01930) (OACA01930)
Immunogen Recombinant Human GTPase KRas protein (2-168AA)
Uniprot ID P01116
Protein Name GTPase KRas
Publications

Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS. J Clin Med. 8, (2019). 31635338

Protein Accession # NP_004976.2; NP_203524.1; XP_006719132.1
Purification Protein G Purified
Nucleotide Accession # NM_004985.4; NM_033360.3; XM_006719069.2
Gene Symbol KRAS
Predicted Species Reactivity Human
Application WB
Image 1

 

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