| Product Number |
OACA00380 |
| Product Page |
www.avivasysbio.com/efna1-antibody-fitc-conjugated-oaca00380.html |
| Name |
EFNA1 Antibody - FITC Conjugated (OACA00380) |
| Isotype |
IgG |
| Conjugation |
FITC |
| NCBI Gene Id |
94268 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purity |
Caprylic Acid Ammonium Sulfate Precipitation purified |
| Gene Full Name |
ephrin A1 |
| Alias Symbols |
B61;EPH-related receptor tyrosine kinase ligand 1;ephrin-A1;immediate early response protein B61;LERK-1. |
| Product Format |
Liquid |
| Reference |
[1] Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis.Takahashi H., Ikeda T.Oncogene 11:879-883(1995)
[2] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamGenome Res. 14:2121-2127(2004) |
| Description of Target |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for EFNA1 Antibody - FITC Conjugated (OACA00380) (OACA00380) |
| Immunogen |
Recombinant Rat Ephrin-A1 protein (18-182AA) |
| Storage Buffer |
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
P97553 |
| Protein Name |
Ephrin-A1 |
| Protein Accession # |
NP_004419.2; NP_872626.1 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_004428.2; NM_182685.1 |
| Gene Symbol |
Efna1 |
| Predicted Species Reactivity |
Rat |
| Application |
WB |
| Image 1 | |
|
