| Product Number |
OACA00372 |
| Product Page |
www.avivasysbio.com/dnmt3a-antibody-fitc-conjugated-oaca00372.html |
| Name |
DNMT3A Antibody - FITC Conjugated (OACA00372) |
| Isotype |
IgG |
| Conjugation |
FITC |
| NCBI Gene Id |
1788 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purity |
Caprylic Acid Ammonium Sulfate Precipitation purified |
| Gene Full Name |
DNA methyltransferase 3 alpha |
| Alias Symbols |
cysteine methyltransferase DNMT3A;DNA (cytosine-5-)-methyltransferase 3 alpha;DNA (cytosine-5)-methyltransferase 3A;DNA cytosine methyltransferase 3A2;DNA methyltransferase HsaIIIA;DNA MTase HsaIIIA;DNMT3A2;HESJAS;M.HsaIIIA;TBRS. |
| Product Format |
Liquid |
| Reference |
[1] Cloning, expression and chromosome locations of the human DNMT3 gene family.'Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999)
[2] A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.'Chen T., Ueda Y., Xie S., Li E.J. Biol. Chem. 277:38746-38754(2002)
[3] Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.'Kim G.-D., Ni J., Kelesoglu N., Roberts R.J., Pradhan S.EMBO J. 21:4183-4195(2002) |
| Description of Target |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for DNMT3A Antibody - FITC Conjugated (OACA00372) (OACA00372) |
| Immunogen |
Recombinant Human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA) |
| Storage Buffer |
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
Q9Y6K1 |
| Protein Name |
DNA (cytosine-5)-methyltransferase 3A |
| Protein Accession # |
NP_072046.2; NP_715640.2; NP_783328.1; NP_783329.1; XP_005264232.1; XP_005264234.1 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_022552.4; NM_153759.3; NM_175629.2; NM_175630.1; XM_005264175.3; XM_005264177.3 |
| Gene Symbol |
DNMT3A |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Image 1 | |
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