| Product Number |
OABF01657 |
| Product Page |
www.avivasysbio.com/slc5a8-antibody-oabf01657.html |
| Name |
SLC5A8 Antibody (OABF01657) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
160728 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
solute carrier family 5 member 8 |
| Description |
|
| Alias Symbols |
AIT;apical iodide transporter;electrogenic sodium monocarboxylate cotransporter;SMCT;SMCT1;sodium iodide-related cotransporter;sodium-coupled monocarboxylate transporter 1;solute carrier family 5 (iodide transporter), member 8;solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8;Solute carrier family 5 member 8. |
| Product Format |
Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for SLC5A8 Antibody (OABF01657) |
| Additional Information |
Subcellular location: Extracellular. |
| Application Info |
WB: 1:100~1000
IHC-P: 1:100~500
Fluorescent-IHC: 1:50~200 |
| Immunogen |
KLH conjugated synthetic peptide derived from human SLC5A8 |
| Intended Use |
For research use only. Not intended for diagnostic or therapeutic use. |
| Uniprot ID |
Q8N695 |
| Protein Name |
Sodium-coupled monocarboxylate transporter 1 |
| Publications |
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats. Acta Physiol (Oxf). 226, e13256 (2019). 30656835 |
| Purification |
Protein A Purified |
| Gene Symbol |
SLC5A8 |
| Predicted Species Reactivity |
Bovine|Chicken|Dog|Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | Human colon carcinoma
 | Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-SLC5A8 Polyclonal Antibody, Unconjugated (OABF01657) at 1:200 followed by conjugation to the secondary antibody and DAB staining. |
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