PIK3CD Antibody (Phospho-Tyr524) (OABF01584)

Data Sheet
 
Product Number OABF01584
Product Page www.avivasysbio.com/pik3cd-antibody-phospho-tyr524-oabf01584.html
Name PIK3CD Antibody (Phospho-Tyr524) (OABF01584)
Isotype IgG
Conjugation Unconjugated
NCBI Gene Id 5293
Host Rabbit
Clonality Polyclonal
Concentration 1 ug/ul
Gene Full Name phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Alias Symbols APDS;IMD14;IMD14A;IMD14B;p110D;P110DELTA;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 20;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20;phosphoinositide-3-kinase C;phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta;PI3K;PI3Kdelta;PI3-kinase p110 subunit delta;ptdIns-3-kinase subunit p110-delta;ROCHIS.
Product Format Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Description of Target Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.
Reconstitution and Storage -20°C
Datasheets/Manuals Printable datasheet for PIK3CD Antibody (Phospho-Tyr524) (OABF01584)
Additional Information Subcellular location: Cytoplasm
Additional Information Modification: Phosphorylation (Tyr524)
Application Info WB: 1:100 - 1000
IHC-P: : 1:100 - 500
Immunogen KLH conjugated synthetic phosphopeptide derived from human PIK3CD around the phosphorylation site of Tyr524
Uniprot ID O00329
Protein Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Purification Protein A Purified
Gene Symbol PIK3CD
Predicted Species Reactivity Bovine|Chicken|Dog|Horse|Human|Mouse|Porcine|Rat
Application Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
Image 1
Human colon carcinoma
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-phospho-PI 3 Kinase p110 delta (Tyr524) Polyclonal Antibody, Unconjugated (OABF01584) at 1:200 followed by conjugation to the secondary antibody and DAB staining
 

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