| Product Number |
OABF01376 |
| Product Page |
www.avivasysbio.com/prkag3-antibody-oabf01376.html |
| Name |
PRKAG3 Antibody (OABF01376) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
53632 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
protein kinase AMP-activated non-catalytic subunit gamma 3 |
| Alias Symbols |
5'-AMP-activated protein kinase subunit gamma-3;5'-AMP-activated protein kinase, gamma-3 subunit;AMPK gamma3;AMPK gamma-3 chain;AMPK subunit gamma-3;AMPKG3;protein kinase, AMP-activated, gamma 3 non-catalytic subunit;SMGMQTL. |
| Product Format |
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for PRKAG3 Antibody (OABF01376) |
| Additional Information |
Subcellular location: |
| Application Info |
WB: 1:100 - 1000
IHC-P: : 1:100 - 500 |
| Immunogen |
KLH conjugated synthetic peptide derived from human AMPK gamma 3 |
| Uniprot ID |
Q9UGI9 |
| Protein Name |
5'-AMP-activated protein kinase subunit gamma-3 |
| Purification |
Protein A Purified |
| Gene Symbol |
PRKAG3 |
| Predicted Species Reactivity |
Bovine|Horse|Human|Mouse|Other|Porcine|Rabbit|Rat|Sheep |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | Human rectal carcinoma
 | Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-AMPK gamma 3/PRKAG3 Polyclonal Antibody, Unconjugated (OABF01376) at 1:200 followed by conjugation to the secondary antibody and DAB staining. |
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