Product Number |
OABF01103 |
Product Page |
www.avivasysbio.com/lpar1-antibody-oabf01103.html |
Name |
LPAR1 Antibody (OABF01103) |
Isotype |
IgG |
Conjugation |
Unconjugated |
NCBI Gene Id |
1902 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1 ug/ul |
Gene Full Name |
lysophosphatidic acid receptor 1 |
Alias Symbols |
edg-2;EDG2;endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2;Gpcr26;LPA receptor 1;LPA1;LPA-1;lysophosphatidic acid receptor 1;lysophosphatidic acid receptor Edg-2;Mrec1.3;rec.1.3;ventricular zone gene 1;vzg-1;VZG1. |
Product Format |
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
Description of Target |
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). |
Reconstitution and Storage |
-20°C |
Datasheets/Manuals |
Printable datasheet for LPAR1 Antibody (OABF01103) |
Additional Information |
Subcellular location: Cytoplasm |
Application Info |
WB: 1:100 - 1000 IHC-P: : 1:100 - 500 |
Immunogen |
KLH conjugated synthetic peptide derived from human EDG2/LPAR1 |
Uniprot ID |
Q92633 |
Protein Name |
Lysophosphatidic acid receptor 1 |
Purification |
Protein A Purified |
Gene Symbol |
LPAR1 |
Predicted Species Reactivity |
Bovine|Chicken|Dog|Horse|Human|Mouse|Rat|Sheep |
Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot |
Image 1 | Human pancreatic cancer
| Formalin-fixed and paraffin embedded human pancreatic cancer labeled with Anti-EDG2/LPA1 Polyclonal Antibody, Unconjugated (OABF01103) at 1:400 followed by conjugation to the secondary antibody and DAB staining |
| Image 2 | L1 Mouse liver lysates, L2 Mouse cerebrum lysates
| L1 Mouse liver lysates, L2 Mouse cerebrum lysates probed with Anti- EDG2/LPA1 Polyclonal Antibody, Unconjugated (OABF01103) at 1:300 in 4C. Followed by conjugation to secondary antibody at 1:2000 90min in 37C. Predicted band and observed band size: 41kD |
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