| Product Number |
OABF00369 |
| Product Page |
www.avivasysbio.com/cxcr4-antibody-oabf00369.html |
| Name |
CXCR4 Antibody (OABF00369) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
7852 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
C-X-C motif chemokine receptor 4 |
| Alias Symbols |
CD184;CD184 antigen;chemokine (C-X-C motif) receptor 4;C-X-C chemokine receptor type 4;D2S201E;FB22;fusin;HM89;HSY3RR;LAP3;LAP-3;LCR1;LESTR;leukocyte-derived seven transmembrane domain receptor;lipopolysaccharide-associated protein 3;LPS-associated protein 3;neuropeptide Y receptor Y3;neuropeptide Y3 receptor;NPY3R;NPYR;NPYRL;NPYY3R;SDF-1 receptor;seven transmembrane helix receptor;seven-transmembrane-segment receptor, spleen;stromal cell-derived factor 1 receptor;WHIM;WHIMS;WHIMS1. |
| Product Format |
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for CXCR4 Antibody (OABF00369) |
| Additional Information |
Subcellular location: Cytoplasm |
| Application Info |
WB: 1:100 - 1000
FC: 1:20 - 100
IHC-P: : 1:100 - 500 |
| Immunogen |
KLH conjugated synthetic peptide derived from human CXCR4 |
| Purification |
Protein A Purified |
| Gene Symbol |
CXCR4 |
| Predicted Species Reactivity |
Bovine|Human|Mouse|Rabbit|Rat |
| Application |
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | rat brain, rat kidney
 | L1: rat brain lysates L2: rat kidney lysates probed with Anti- CD184/CXCR4 Polyclonal Antibody, Unconjugated (OABF00369) at 1:200 overnight at 4C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37C. Predicted band 39kD.Observed band 39kD |
| | Image 2 | mouse lung
 | Mouse lung lysates probed with Anti-CXCR4 Polyclonal Antibody (OABF00369) at 1:300 overnight at 4C. Followed by conjugation to secondary antibody ) at 1:5000 for 90 min at 37C. |
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