| Product Number |
OABF00092 |
| Product Page |
www.avivasysbio.com/ntrk1-antibody-oabf00092.html |
| Name |
NTRK1 Antibody (OABF00092) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
4914 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
neurotrophic receptor tyrosine kinase 1 |
| Alias Symbols |
gp140trk;high affinity nerve growth factor receptor;MTC;Neurotrophic tyrosine kinase receptor type 1;neurotrophic tyrosine kinase, receptor, type 1;Oncogene TRK;p140-TrkA;TRK;TRK1;TRK1-transforming tyrosine kinase protein;Trk-A;TRKA;tropomyosin-related kinase A;Tyrosine kinase receptor;tyrosine kinase receptor A. |
| Product Format |
Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for NTRK1 Antibody (OABF00092) |
| Additional Information |
Subcellular location: Cytoplasm |
| Application Info |
WB: 1:100~1000
IHC-P: 1:100~500
Fluorescent-IHC: 1:50~200 |
| Immunogen |
KLH conjugated synthetic peptide derived from human Trk A |
| Uniprot ID |
P04629 |
| Protein Name |
High affinity nerve growth factor receptor |
| Purification |
Protein A Purified |
| Gene Symbol |
NTRK1 |
| Predicted Species Reactivity |
Chicken|Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | Human lung carcinoma
 | Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Trk A/B/C Polyclonal Antibody, Unconjugated (OABF00092) at 1:200 followed by conjugation to the secondary antibody and DAB staining |
| | Image 2 | Rat brain
 | Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Trk A/B/C Polyclonal Antibody, Unconjugated (OABF00092) at 1:200 followed by conjugation to the secondary antibody and DAB staining |
|
|
